Chromosome distribution between two restitution nuclei in a cell following colchicine treatment

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Abstract
Roots of Zea mays L., Secale cereale L., Vicia faba, L., Allium cepa L. and Hordeum vulgare L. were treated with colchicine. C-metaphases were observed in cells which had chromosomes present in 2 distinct groups, not the typical single group. Chromosome distribution into 2 groups was not followed by chromatid segreagtion; instead, the chromosomes underwent restitution and binucleate-interphase cells were formed. The distribution of chromosomes into 2 groups is functionally equivalent to chromosome nondisjunction. In some cases, the 2 groups contained different numbers of chromosomes; these gave rise to aneuploid nuclei. The pattern of chromosome distribution into 2 groups is not random; it may reflect chromosome position in the interphase or prophase nucleus. The results are related to the formation or genotypic and phenotypic mosaics produced by treatment with other microtubule inhibiting drugs or in response to cell division mutants and to the spatial distribution of chromosomes within the nucleus.

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