Evidence against VIP or substance P being the transmitter in non-cholinergic excitatory nerves supplying the guinea-pig bladder
- 1 June 1985
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 37 (6) , 432-434
- https://doi.org/10.1111/j.2042-7158.1985.tb03031.x
Abstract
In the guinea-pig bladder, contractile responses to substance P (0.3 μM) and VIP (3 μM) were unaffected by P2-purinoceptor desensitization with α,β-methylene ATP (3 times 10−6M), while the responses to stimulation of the non-cholinergic excitatory nerves (4–16 Hz) were abolished. The evidence presented suggests that ATP or a related purine nucleotide, and not VIP or substance P, is responsible for the non-cholinergic excitatory component of the nerve-mediated response.Keywords
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