Synthetic studies of nucleic acids on polymer supports. Part I. Oligodeoxyribonucleotide synthesis on an insoluble polymer support
- 1 January 1967
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society C: Organic
- Vol. 22, 2438-2442
- https://doi.org/10.1039/j39670002438
Abstract
The synthesis of thymidylyl-(5′→ 3′)-thymidylyl-(5′→ 3′)-thymidine 5′-phosphate using an insoluble polystyrene support is described. The first nucleotide is attached to the polymer by a phosphoramidate linkage which is cleaved by mild acid treatment to release the product.Keywords
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