Pituitary-Thyroid Responsiveness to Intramuscular Thyrotropin-Releasing Hormone Based on Analyses of Serum Thyroxine, Tri-Iodothyronine and Thyrotropin Concentrations

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Abstract
To develop a test of pituitary-thyroid responsiveness to thyrotropin-releasing hormone that would obviate the need for measuring serum thyrotropin, we determined serum thyrotropin, thyroxine, and tri-iodothyronine concentrations before and at frequent intervals after the intramuscular administration of 2 mg of thyrotropin-releasing hormone in normal subjects and in patients with a variety of thyroid disorders. In specimens obtained four and five hours after administration of the hormone to normal subjects, serum thyroxine concentration increased 2.4±0.7 μg per 100 ml (mean±S.D.) over base-line values, the magnitude of increase being greater than 1.5 μg per 100 ml in 32 of 34 subjects.

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