A rapid extraction method preliminary to analysis for drugs in urine is described. Extraction columns containing purified cotton fiber (JETUBE, Manhattan Instrument Co., Santa Monica, Calif.) are shown to give high (approximately 90-97%) extraction efficiencies for some commonly prescribed or abused drugs, notably phenobarbital, amphetamine, morphine, and methadone. Analysis time, extraction efficiency, convenience, and eluate purity with a modified JET procedure are shown to be superior to results obtained with XAD-2 resin columns.