Role of Granulocyte Colony-Stimulating Factor in the Immune Response to Acute Bacterial Infection in the Nonneutropenic Host: An Overview
- 1 February 1994
- journal article
- review article
- Published by Oxford University Press (OUP) in Clinical Infectious Diseases
- Vol. 18 (Supplement) , S197-S204
- https://doi.org/10.1093/clinids/18.supplement_2.s197
Abstract
Granulocyte colony-stimulating factor (G-CSF) regulates the production and potentiates the function of neutrophils. Studies of animals and patients have shown that levels of G-CSF increase in response to certain types of acute bacterial infection; for example, levels of this factor increase in the lungs and in serum during pneumonia. Investigations of several nonneutropenic animal models of severe bacterial infection have indicated that exogenous recombinant G-CSF—either alone or in combination with antibiotics—can significantly enhance host defenses and improve rates of survival. Trials of recombinant G-CSF for the prevention or treatment of serious infection in clinical settings have recently been initiated.Keywords
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