Ciamexone-A New Highly Selective Immunosuppressive Compound

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Abstract
A local graft-vs.-host reaction [GVHR] between lymphocytes of Balb-c mice and its F-1-generation CB6F1 can be induced because of differences in products of the class II of the major histocompatibility complex (Ir). In this local mixed lymphocyte reaction mainly T-helper cells and B-cells are involved. An induction of a delayed type hypersensitivity reaction with oxazolon significantly decreases the local GVHR. Cyclosporin A depresses the local GVHR and the delayed type hypersensitivity in mice whereas Ciamexone, a 2-cyanaziridine derivative, very selectively only suppresses the local GVHR and increases the delayed type hypersensitivity.