Effects of Chronic Ethanol Administration on Canine Exocrine Pancreatic Secretion

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Abstract
The effects on pancreatic exocrine secretion of an acute intravenous ethanol injection (1.3 g/kg) and of 12 months of intragastric alcohol feeding (2.0 g/kg) were studied in 5 dogs provided with chronic pancreatic and gastric fistulae (Thomas cannula). Dogs were subjected either to a continuous intravenous injection of secretin alone (GIH, 1.0 CU/ kg/h) or associated with CCK (GIH, 3.0 U/kg/h). Twelve months of alcohol treatment first abolishes and then reverses the inhibitory effects of acute intravenous ethanol on pancreatic secretion. Ethanol treatment, in its earlier stages, provokes cholecystokinin-mediated higher plateau secretory values. This reflects increased sensitivity of ‘pancreon’ cells to the hormone. A subsequent fall of plateau values indicates a lesion of the gland. This is apparently related to the excretion of protein plugs and microstones through the main pancreatic duct.

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