Acylation of in situ generated trimethylsilyl diethylphosphonoacetate using magnesium chloride–triethylamine: a practical synthesis of β-keto phosphonates
- 1 January 1997
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 9,p. 1361-1364
- https://doi.org/10.1039/a607683a
Abstract
In situ generated trimethylsilyl diethylphosphonoacetate from diethyl phosphonoacetic acid can be acylated with carboxylic acid chlorides in the presence of magnesium chloride to prepare a variety of β-keto phosphonates. This synthetic method is suitable for the preparation of β-keto phosphonates in the laboratory and also for large-scale production.Keywords
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