Radiation-induced transgenerational instability
- 13 October 2003
- journal article
- review article
- Published by Springer Nature in Oncogene
- Vol. 22 (45) , 7087-7093
- https://doi.org/10.1038/sj.onc.1206993
Abstract
To date, the analysis of mutation induction has provided an irrefutable evidence for an elevated germline mutation rate in the parents directly exposed to ionizing radiation and a number of chemical mutagens. However, the results of numerous publications suggest that radiation may also have an indirect effect on genome stability, which is transmitted through the germ line of irradiated parents to their offspring. This review describes the phenomenon of transgenerational instability and focuses on the data showing increased cancer incidence and elevated mutation rates in the germ line and somatic tissues of the offspring of irradiated parents. The possible mechanisms of transgenerational instability are also discussed.Keywords
This publication has 69 references indexed in Scilit:
- Leukaemia and non‐Hodgkin's lymphoma in children of male Sellafield radiation workersInternational Journal of Cancer, 2002
- Ionising radiation and mutation induction at mouse minisatellite lociMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2001
- Transgenerational Effects of Preconception Paternal Contamination with55FeRadiation Research, 2001
- Investigation of lung tumour induction in C3HHeH mice, with and without tumour promotion with urethane, following paternal X-irradiationMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1998
- A Novel Unstable Mouse VNTR Family Expanded from SINE B1 ElementsGenomics, 1998
- In vitro fertilization rate of mouse oocytes with spermatozoa from the F1 offspring of males irradiated with 1.0 Gy 137Cs γ-raysMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1997
- A Tetranucleotide Repeat Mouse Minisatellite Displaying Substantial Somatic Instability during Early Preimplantation DevelopmentGenomics, 1993
- Promotion of skin tumors by 12-O-tetradecanoylphorbol-13-acetate in two generations of descendants of male mice exposed to X-ray irradiationMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1993
- Increased multiplicity of lung adenomas in five generations of mice treated with benz(a)pyrene when pregnantCancer Letters, 1990
- Characterization of a highly unstable mouse minisatellite locus: Evidence for somatic mutation during early developmentGenomics, 1989