Autoregulation: A Role for a Biosynthetic Enzyme in the Control of Gene Expression
- 1 October 1973
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 70 (10) , 2757-2761
- https://doi.org/10.1073/pnas.70.10.2757
Abstract
It was previously proposed, primarily on the basis of evidence in vitro , that L-threonine deaminase, the ilvA gene product, is required for repression of its own synthesis and for repression of the other genes in the ilv-ADE operon. In this communication, evidence in vivo is presented that supports this autoregulatory model. Further evidence is presented that suggests that L-threonine deaminase is also required for induction of the ilvC gene product. The autoregulatory model is presented in an expanded form to include recent evidence that L-threonine deaminase (EC 4.2.1.16) is a central element for repression of the ilvADE and ilvB operons, and for induction of the ilvC operon.Keywords
This publication has 15 references indexed in Scilit:
- Two forms of biosynthetic acetohydroxy acid synthetase in SalmonellatyphimuriumBiochemical and Biophysical Research Communications, 1972
- Isoleucine Auxotrophy as a Consequence of a Mutationally Altered Isoleucyl-Transfer Ribonucleic Acid SynthetaseJournal of Bacteriology, 1971
- SPECIFIC BINDING OF LEUCYL TRANSFER RNA TO AN IMMATURE FORM OF L-THREONINE DEAMINASE: ITS IMPLICATIONS IN REPRESSIONProceedings of the National Academy of Sciences, 1970
- Threonine deaminase from Salmonella typhimurium. 3. The intermediate substructure.1970
- Ligand-Induced Maturation of Threonine DeaminaseScience, 1970
- The metabolism of valine and isoleucine in Escherichia coli XVII the role of induction in the depression of acetohydroxy acid isomeroreductaseBiochemical and Biophysical Research Communications, 1969
- STUDIES ON REPRESSION OF THE HISTIDINE OPERON, II. THE ROLE OF THE FIRST ENZYME IN CONTROL OF THE HISTIDINE SYSTEMProceedings of the National Academy of Sciences, 1969
- Roles of amino acid activating enzymes in cellular physiology.1966
- Translational Control of Gene ExpressionCold Spring Harbor Symposia on Quantitative Biology, 1966
- Regulation of protein synthesis: an alternative to the repressor-operator hypothesis.1965