Ammonia Disposal in Reye's Syndrome

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Abstract
IN 1963 R.D.K. Reye and his colleagues described a constellation of clinical signs and symptoms in children consisting of encephalopathy with fatty infiltration of the viscera. Since that time this syndrome characterized by a prodromal viral or viral-like illness, followed by pernicious vomiting and increasing cerebral cortical dysfunction, has been recognized with increasing frequency. The pattern of fatty infiltration of the viscera, described by Reye et al. is specific, consisting, in the liver, of multiple small droplets of lipid uniformly distributed throughout the hepatocyte.1 Hepatic dysfunction is reflected in increased serum ammonia concentration, increased serum glutamic oxalacetate activity, and prolongation . . .