A statistical toolbox for metagenomics: assessing functional diversity in microbial communities
Open Access
- 23 January 2008
- journal article
- Published by Springer Nature in BMC Bioinformatics
- Vol. 9 (1) , 34
- https://doi.org/10.1186/1471-2105-9-34
Abstract
The 99% of bacteria in the environment that are recalcitrant to culturing have spurred the development of metagenomics, a culture-independent approach to sample and characterize microbial genomes. Massive datasets of metagenomic sequences have been accumulated, but analysis of these sequences has focused primarily on the descriptive comparison of the relative abundance of proteins that belong to specific functional categories. More robust statistical methods are needed to make inferences from metagenomic data. In this study, we developed and applied a suite of tools to describe and compare the richness, membership, and structure of microbial communities using peptide fragment sequences extracted from metagenomic sequence data.Keywords
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