Stimulation by somatostatin of dephosphorylation of membrane proteins in pancreatic cancer MIA PaCa‐2 cell line
- 7 January 1985
- journal article
- Published by Wiley in FEBS Letters
- Vol. 179 (2) , 252-256
- https://doi.org/10.1016/0014-5793(85)80529-9
Abstract
A membrane receptor and a cytosolic receptor for somatostatin were found in a human undifferentiated pancreatic cancer cell line (MIA PaCa-2). Binding of somatostatin to this membrane receptor activates dephosphorylation of a phosphotyrosyl-membrane protein whose phosphorylation was promoted by epidermal growth factor (EGF). Vanadate, a purported inhibitor of dephosphorylation, interferes with the action of somatostatin. These findings suggest a possible biochemical mechanism by which somatostatin may inhibit the growth of human pancreatic cancersKeywords
This publication has 18 references indexed in Scilit:
- SomatostatinNew England Journal of Medicine, 1983
- SomatostatinNew England Journal of Medicine, 1983
- Evidence for an intracellular somatostatin receptor in pancreas: A comparative study with reference to gastric mucosaBiochemical and Biophysical Research Communications, 1982
- Physiology and Pharmacology of LHRH and SomatostatinAnnual Review of Pharmacology and Toxicology, 1982
- Vanadate, epidermal growth factor and the stimulation of DNA synthesisBiochemical and Biophysical Research Communications, 1981
- The ChalonesPublished by Springer Nature ,1981
- Polypeptide growth factors: Some structural and mechanistic considerationsJournal of Supramolecular Structure, 1980
- Hypothalamic Regulatory HormonesAnnual Review of Biochemistry, 1978
- Human pancreatic carcinoma (mia paca‐2) in continuous culture: Sensitivity to asparaginaseInternational Journal of Cancer, 1977
- Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Nature, 1970