Effect of Insulin and Glucagon on Fulminant Murine Hepatitis

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Abstract
Fulminant hepatic failure is the most serious complication of viral hepatitis, the mortality of patients with Stage 4 coma being approximately 80 to 90 per cent.1 2 3 4 Most of the survivors recover completely, at least in part because of the remarkable capacity of the liver to regenerate.5 Attempts to sustain life by supportive measures until spontaneous regeneration could occur have so far failed to reduce mortality.6 7 8 We have therefore adopted an approach based on recent studies by Bucher and Swaffield showing that in laboratory animals, hepatic regeneration can be enhanced by the synergistic action of two pancreatic hormones — insulin and . . .