ANOMALOUS BEHAVIORAL-RESPONSE TO IMIDAZOLEACETIC ACID, A GABA AGONIST, IN ANIMALS TREATED CHRONICALLY WITH HALOPERIDOL

  • 1 January 1980
    • journal article
    • research article
    • Vol. 15  (1) , 21-35
Abstract
Short-term haloperidol treatment decreases the stimulant effects of drugs with dopaminelike actions, while withdrawal from long-term haloperidol treatment enhances the effects of such drugs. Withdrawal from long-term haloperidol treatment decreases or eliminates the tendency for imidazole-4-acetic acid, a GABA agonist, to decrease the locomotor activity of mice. Acute haloperidol treatment did not duplicate these effects. Apparently chronic administration of haloperidol causes changes in a variety of systems in the brain and the GABA system in particular is profoundly altered by such treatment.