EO9: A novel bioreductive alkylating indoloquinone with preferential solid tumour activity and lack of bone marrow toxicity in preclinical models
- 31 December 1993
- journal article
- Published by Elsevier in European Journal Of Cancer
- Vol. 29 (6) , 897-906
- https://doi.org/10.1016/s0959-8049(05)80434-4
Abstract
No abstract availableKeywords
This publication has 23 references indexed in Scilit:
- In vitro activity of the novel indoloquinone EO-9 and the influence of pH on cytotoxicityBritish Journal of Cancer, 1992
- The Role of NAD(P)H: Quinone Reductase (EC 1.6.99.2, DT-Diaphorase) in the Reductive Bioactivation of the Novel Indoloquinone Antitumor Agent E09Cancer Communications, 1991
- Feasibility of a High-Flux Anticancer Drug Screen Using a Diverse Panel of Cultured Human Tumor Cell LinesJNCI Journal of the National Cancer Institute, 1991
- The clonogenic assay with human tumor xenografts: Evaluation, predictive value and application for drug screeningAnnals of Oncology, 1990
- New Colorimetric Cytotoxicity Assay for Anticancer-Drug ScreeningJNCI Journal of the National Cancer Institute, 1990
- DT-diaphorase: questionable role in mitomycin C resistance, but a target for novel bioreductive drugs?British Journal of Cancer, 1989
- Display and Analysis of Patterns of Differential Activity of Drugs Against Human Tumor Cell Lines: Development of Mean Graph and COMPARE AlgorithmJNCI Journal of the National Cancer Institute, 1989
- The differential hypoxic cytotoxicity of bioreductive agents determined in vitro by the MTT assayInternational Journal of Radiation Oncology*Biology*Physics, 1989
- Colony assay with human tumor xenografts, murine tumors and human bone marrow. Potential for anticancer drug developmentEuropean Journal of Cancer and Clinical Oncology, 1987
- Mitomycin analogs I. Indoloquinones as (potential) bisalkylating agentsTetrahedron, 1987