Personality, Prior Drug Use, and Introspective Experience during Nitrous Oxide Intoxication

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Abstract
Data on some personality characteristics and prior drug experiences of 60 volunteer young men were compared with their subjective psychological responses while inhaling 40% N2O-O2 mixtures for 20 min in a naturalistic laboratory setting. A rather specific trait openness to internal reverie-type experiences was very significantly related to a wide variety of drug responses, while several more general traits, including introversion and neuroticism, and openness to nonreverie mental experiences were unrelated to drug response. Prior illicit drug use was related only to mood on nitrous oxide and not to other effects. Implications of the findings in the field of drug abuse are discussed.

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