Coordination Chemical Studies of Some Polymeric Transition Metal Complexes with Neomycin and Their Biological Activity Uses. Indirect Determination of Neomycin by Atomic Absorption Spectroscopy (AAS)

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Abstract
A new series of polymeric[M(Neom)H2 O)x]n complexes have been prepared; where M= Co(II), Ni(II), Cu(II) or Zn(II) ions, Neom = neomycin and X = 2–4. The complexes have been characterized by elemental analysis, conductance and magetic moment measurements. IR spectra indicated that the bonding between neomycin and transition metal ions takes place through M-O bonds. Electronic and EPR spectra of the solid complexes are measured in order to gain information about their structurs and geometry. X- ray diffraction patterns indicated that the complexes are amorphous. The biological activity of the complexes formed has been tested towards eight microorganisms and compared with the activity of neomycin itself. A new method is described for the indirect estimation of neomycin by atomic absorption spectroscopy (AAS) using carbonate as an auxiliary ligand. The results obtained either for the pure form or in pharmaceutical formulations are accurate and precise.