Studies In Experimental Tetanus Infection

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Abstract
Evidence is given that for penicillin to prevent experimental tetanus in mice a 4-day period of treatment is satisfactory. To prevent tetanus by passive immunisation the antitoxin must remain in the circulation for 9 days. In either case Cl. tetani frequently survives at the injection site. To account for these observations it is suggested that when tetanus bacilli grow in an anaerobic lesion, the local conditions are altered so that the time for which the lesion remains suitable for multiplication of anaerobic bacteria is prolonged. This conclusion is supported by the following findings.

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