Physiologic Availability and in Vitro Release of Riboflavin in Sustained-Release Vitamin Preparations

Abstract
SUSTAINED-release preparations are designed to contain in one dosage form the equivalent of several single doses of a drug, which is released to the body over an extended period, thereby producing sustained clinical effects. Various types of sustained-release products for oral administration are appearing on the market in increasing numbers, indicating continued commercial interest in this type of medication, as well as increased acceptance by the medical profession. Although many of these preparations have undoubtedly been tested clinically, and found to have the desired effects, it has been shown that there are products on the market that purport to have . . .