Identification and localization of glycine in the inner core lipopolysaccharide of Neisseria meningitidis
Open Access
- 28 August 2002
- journal article
- research article
- Published by Wiley in European Journal of Biochemistry
- Vol. 269 (17) , 4169-4175
- https://doi.org/10.1046/j.1432-1033.2002.03131.x
Abstract
The amino acid glycine is identified as a component of the inner core oligosaccharide in meningococcal lipopolysaccharide (LPS). Ester‐linked glycine residues were consistently found by mass spectrometry experiments to be located on the distal heptose residue (HepII) in LPS from several strains of Neisseria meningitidis. Nuclear magnetic resonance studies confirmed and extended this observation locating the glycine residue at the 7‐position of the HepII molecule in L3 and L4 immunotype strains.Keywords
This publication has 19 references indexed in Scilit:
- Structural analysis of the lipopolysaccharide from Neisseria meningitidis strain BZ157 galE: localisation of two phosphoethanolamine residues in the inner core oligosaccharideCarbohydrate Research, 2002
- Identification of a gene (lpt‐3) required for the addition of phosphoethanolamine to the lipopolysaccharide inner core of Neisseria meningitidis and its role in mediating susceptibility to bactericidal killing and opsonophagocytosisMolecular Microbiology, 2002
- Glycine is a common substituent of the inner core in Haemophilus influenzae lipopolysaccharide.Glycobiology, 2001
- The structure of the lipooligosaccharide (LOS) from the -1,2-N-acetyl glucosamine transferase (rfaKNMB) mutant strain CMK1 of Neisseria meningitidis: implications for LOS inner core assembly and LOS-based vaccinesGlycobiology, 2001
- Structural basis of the Neisseria meningitidis immunotypes including the L4 and L7 immunotypesCarbohydrate Research, 1997
- The occurrence of glycine in bacterial lipopolysaccharidesFEMS Immunology & Medical Microbiology, 1996
- Lipo-oligosaccharide immunotyping of Neisseria meningitidis by a whole-cell ELISA with monoclonal antibodiesJournal of Medical Microbiology, 1994
- Cloning and molecular analysis of the galE gene of Neisseria meningitidls and its role in lipopolysaccharide biosynthesisMolecular Microbiology, 1993
- Structure of the L1 and L6 core oligosaccharide epitopes of NeisseriameningitidisCanadian Journal of Chemistry, 1990
- The structure of an R-type oligosaccharide core obtained from some lipopolysaccharides of Neisseria meningitidisCarbohydrate Research, 1983