Variations in Solid-Phase Extraction of Basic Drugs Using Bonded Silica. I. Manufacturer-To-Manufacturer Variations
- 1 June 1991
- journal article
- research article
- Published by Taylor & Francis in Journal of Liquid Chromatography
- Vol. 14 (9) , 1645-1658
- https://doi.org/10.1080/01483919108049642
Abstract
Manufacturer-to-manufacturer variations of solid—phase extraction (SPE) of basic drugs from serum and water using C18-silica were studied and solute-sorbent interactions discussed on the basis of elution profiles obtained after elution of two model drugs from C18-sorbents of five vendors. In addition to manfacturer-to-manufacturer variations, differences were observed also after SPE from water and from serum indicating an inclusion of endogens from serum to processes run in SPE. Differences in polar properties of the sorbents were found to be the main cause of the variations.Keywords
This publication has 10 references indexed in Scilit:
- Polar Interactions in Solid-Phase Extraction of Basic Drugs by Octadecylsilanized SilicaJournal of Chromatographic Science, 1990
- Selective solid-phase extraction of basic drugs by C8-silica. Discussion of possible interactionsJournal of Pharmaceutical and Biomedical Analysis, 1990
- Sample preparation for biomedical analysisJournal of Chromatography B: Biomedical Sciences and Applications, 1989
- Sample Pretreatment in the Determination of Beta-Blockers in Biological FluidsPublished by Elsevier ,1989
- Improved method for capillary gas—liquid chromatography/nitrogen—phosphorus detection determination of pentacaine in serumJournal of Pharmaceutical and Biomedical Analysis, 1989
- Determination of stobadine, a novel cardioprotective drug, using capillary gas chromatography with nitrogen—phosphorus detection after its selective solid-phase extraction from serumJournal of Chromatography B: Biomedical Sciences and Applications, 1988
- Analysis of drugs from biological fluids using disposable solid phase columnsJournal of Chromatography A, 1987
- The use of C18 bonded silica in the solid phase extraction of basic drugs — possible role for ionic interactions with residual silanolsJournal of Pharmaceutical and Biomedical Analysis, 1987
- Liquid—solid sample preparation in drug analysisJournal of Pharmaceutical and Biomedical Analysis, 1986
- The disposition of the local anaesthetic, pentacaine, in rats and miceBiopharmaceutics & Drug Disposition, 1986