Inhibition of B16-BL6 Melanoma Growth in Mice by Methionine-Enkephalin2
- 1 August 1985
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 75 (2) , 341-344
- https://doi.org/10.1093/jnci/75.2.341
Abstract
The antitumor effect of methionine-enkephalin ([Met]enkephalin) was demonstrated in C57BL/6J mice inoculated with B16-BL6 melanoma cells. Local subcutaneous tumor growth was inhibited with a 50-μg dose daily for 7 or 14 days. The antitumor effect of [Met]enkephalin was inhibited by the administration of the opioid receptor antagonist naloxone. Naloxone alone had no significant effect on tumor growth.Keywords
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