Immunofluorescence studies of florid rheumatic Aschoff lesions

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Abstract
We studied cardiac tissues of a patient who died of severe rheumatic myocarditis. Multiple Aschoff lesions were present throughout both ventricles and auricles. Immunofluorescence studies showed large monocytoid cells staining with OKM1 and anti‐Leu M‐3 as well as anti‐Ia. Scattered T cells in areas of focal myocarditis stained with OKT3. Parallel staining for cardiac myosin‐heavy chain antigens showed patchy dissolution of cardiac muscle fibers and traces of cardiac myosin within large monocytoid Aschoff cells.