The excretion of synthetic oestrogens as ethereal sulphates and monoglucuronides in the rabbit and in man

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Abstract
A method of separating the ethereal sulfates of stilbestrol, hexestrol, dienestrol from the monoglucuronides and free forms is described. A small excretion of synthetic estrogen as ethereal sulfate was found in both man and the rabbit. The method used for working up gives reasonably quantitative results on known synthetic mixtures in urines, so that there is little doubt that the comparatively low overall recoveries obtained in metabolism expts. are not due entirely to inadequate technique, but do indicate a real metabolic breakdown. Results obtained by detn. of the metabolized estrogen as the monoglucuronide are consistently higher than those obtained by hydrolysis of all conjugated forms of estrogen present followed by detn. as free estrogen.