Cerebrospinal Fluid Tau and β-Amyloid
Open Access
- 1 December 2003
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Neurology
- Vol. 60 (12) , 1696-1702
- https://doi.org/10.1001/archneur.60.12.1696
Abstract
ALZHEIMER DISEASE (AD) is a neurodegenerative disorder that produces progressive impairments in memory, language, judgment, insight, behavior, and personality. Pathological features include neurofibrillary tangles composed of hyperphosphorylated tau, neuritic plaques composed of β-amyloid (Aβ) fibrils, and neuronal death with associated cerebral atrophy and gliosis. These pathological changes are most prominent in the hippocampus, entorhinal cortex, and association areas of the neocortex and are believed to be responsible for the clinical features.1Keywords
This publication has 17 references indexed in Scilit:
- Differential Diagnosis of Alzheimer Disease With Cerebrospinal Fluid Levels of Tau Protein Phosphorylated at Threonine 231Archives of Neurology, 2002
- Cerebrospinal fluid tau in dementia disorders: a large scale multicenter study by a Japanese study groupNeurobiology of Aging, 2002
- Accuracy of clinical criteria for AD in the Honolulu–Asia Aging Study, a population-based studyNeurology, 2001
- Amyloid beta vaccination: reduced plaques and improved cognition.Nature Medicine, 2001
- Transient increase in total tau but not phospho-tau in human cerebrospinal fluid after acute strokeNeuroscience Letters, 2001
- Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer diseaseNature Medicine, 2000
- Increased Cerebrospinal Fluid Tau Protein in Multiple SclerosisEuropean Neurology, 2000
- Quantification of tau phosphorylated at threonine 181 in human cerebrospinal fluid: a sandwich ELISA with a synthetic phosphopeptide for standardizationNeuroscience Letters, 2000
- Elevated levels of tau-protein in cerebrospinal fluid of patients with Creutzfeldt–Jakob diseaseNeuroscience Letters, 1997
- The 14-3-3 Brain Protein in Cerebrospinal Fluid as a Marker for Transmissible Spongiform EncephalopathiesNew England Journal of Medicine, 1996