Structure and Chromosomal Localization of the Murine Coxsackievirus and Adenovirus Receptor Gene
- 1 April 2003
- journal article
- research article
- Published by Mary Ann Liebert Inc in DNA and Cell Biology
- Vol. 22 (4) , 253-259
- https://doi.org/10.1089/104454903321908647
Abstract
We analyzed BAC genomic clones encoding the murine coxsackievirus and adenovirus receptor (mCAR). The mCAR gene is situated on the distal portion of murine chromosome 16, and is composed of at least eight exons, with intron-exon boundaries similar to those reported for the human CAR gene. We previously described two cDNAs encoding mCAR isoforms: the extracellular and transmembrane portions of both are encoded by exons 1-6; the cytoplasmic domain of mCAR 1 is encoded by exon 7, whereas mCAR 2 results from an RNA splice linking the proximal portion of exon 7 to an alternative exon 8. RT-PCR analysis of the mCAR RNA 5′-terminus suggests that transcription may begin 141-161 nucleotides upstream of the ATG translational start site.Keywords
This publication has 17 references indexed in Scilit:
- A Zebrafish Coxsackievirus and Adenovirus Receptor Homologue Interacts with Coxsackie B Virus and AdenovirusJournal of Virology, 2002
- A Comparison of Whole-Genome Shotgun-Derived Mouse Chromosome 16 and the Human GenomeScience, 2002
- Characterization of a cDNA Encoding the Bovine Coxsackie and Adenovirus ReceptorBiochemical and Biophysical Research Communications, 2001
- Identification of Alternative Splice Products Encoded by the Human Coxsackie-Adenovirus Receptor GeneBiochemical and Biophysical Research Communications, 2001
- Human Coxsackie-Adenovirus Receptor Is Colocalized With Integrins α v β 3 and α v β 5 on the Cardiomyocyte Sarcolemma and Upregulated in Dilated CardiomyopathyCirculation, 2001
- Genomic organization and chromosomal localization of the human Coxsackievirus B-adenovirus receptor geneHuman Genetics, 1999
- Expression of Coxsackie adenovirus receptor and alphav-integrin does not correlate with adenovector targeting in vivo indicating anatomical vector barriersGene Therapy, 1999
- Isolation of a Common Receptor for Coxsackie B Viruses and Adenoviruses 2 and 5Science, 1997
- Expression and distribution of the receptors for coxsackievirus B3 during fetal development of the Balb/c mouse and of their brain cells in cultureVirus Research, 1996
- Predicting Pol II Promoter Sequences using Transcription Factor Binding SitesJournal of Molecular Biology, 1995