FUNCTIONAL AND ULTRASTRUCTURAL STUDIES OF THE EFFECTS OF HUMAN INTERFERON ON CELL MEMBRANES OF IN VITRO CULTURED CELLS

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Abstract
The effect of human leukocyte interferon on cultured [human] U-amnion cells was examined, and several biological parameters were registered. Multiplication of vesicular stomatitis virus and the virus-produced cytopathogenic effect was prevented. The growth rate of uninfected cells and the spontaneous release of 3H-uridine were reduced. These effects were observed following treatment with units of interferon/ml. No morphological alterations could be detected by scanning electron microscopy after 24 or 72 h treatment with up to 2000 units interferon/ml.