Mechanisms of Erythropoietin Signal Transduction: Involvement of Calcium Channels
- 1 July 1994
- journal article
- review article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 206 (3) , 263-267
- https://doi.org/10.3181/00379727-206-43756
Abstract
Erythropoietin (Epo) induces a dose-dependent increase in intracellular free calcium concentration ([Cai]) in single human BFU-E derived erythroblasts, which is specific for stage of differentiation and mediated through a voltage-independent ion channel permeable to calcium. This minireview examines the regulation of calcium channels by Epo during normal erythroid differentiation, as a model to delineate the immediate signaling events which follow interaction of Epo with its receptor.Keywords
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