The effect of carbidopa and benserazide on human plasma 5-hydroxytryptophan levels
- 1 March 1982
- journal article
- research article
- Published by Springer Nature in Journal Of Neural Transmission-Parkinsons Disease and Dementia Section
- Vol. 53 (1) , 83-87
- https://doi.org/10.1007/bf01243522
Abstract
Peripheral aromatic amino acid decarboxylase inhibitors increase human plasma 5-hydroxytryptophan (5-HTP) levels. However the 5-HTP, which is synthesized in the intestine, is not present in a sufficient quantity to influence brain 5-HT to any significant degree. Thus, peripheral decarboxylase inhibitors are unlikely to affect brain 5-HT function via 5-HTP which is synthesized peripherally.Keywords
This publication has 12 references indexed in Scilit:
- Formation of 5-hydroxykynurenine and 5-hydroxykynurenamine from 5-hydroxytryptophan in rabbit small intestineProceedings of the National Academy of Sciences, 1979
- Liquid chromatographic-fluorometric system for the determination of indoles in physiological samplesAnalytical Chemistry, 1979
- INHIBITION OF HUMAN AND RAT HEPATIC AMINOTRANSFERASE ACTIVITY WITH L-3,4-DIHYDROXYPHENYLALANINE BY INHIBITORS OF PERIPHERAL AROMATIC AMINO-ACID DECARBOXYLASE1979
- Radioenzymatic assay of DOPA (3,4-dihydroxyphenylalanine).Clinical Chemistry, 1978
- Suppression of noradrenaline synthesis in sympathetic nerves by carbidopa, an inhibitor of peripheral dopa decarboxylaseNature, 1977
- The determination of 5-hydroxytryptophan and its metabolites in plasma following administration to manClinica Chimica Acta; International Journal of Clinical Chemistry, 1976
- BRAIN AND PERIPHERAL METABOLISM OF 5-HYDROXYTRYPTOPHAN-C-14 FOLLOWING PERIPHERAL DECARBOXYLASE INHIBITION1976
- SERUM LEVELS OF 5-HYDROXYINDOLE DERIVATES AFTER ADMINISTRATION OF L-5-HYDROXYTRYPTOPHAN ETHYL-ESTER1976
- Attempts to measure endogenous levels of dopa and 5-hydroxytryptophan in rat brainJournal Of Neural Transmission-Parkinsons Disease and Dementia Section, 1975
- Transamination is a Major Pathway of L-Dopa Metabolism following Peripheral Decarboxylase InhibitionNature, 1974