A Randomized, Double-Blind, Placebo-Controlled Trial of Systemically Administered Interferon- , - , or - in Combination with Cryotherapy for the Treatment of Condyloma Acuminatum
- 1 May 1995
- journal article
- clinical trial
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 171 (5) , 1081-1089
- https://doi.org/10.1093/infdis/171.5.1081
Abstract
One hundred fifty-two patients were enrolled in a study to evaluate 3 interferon (IFN) preparations used in combination with cryotherapy for treatment of anogenital warts. Subjects received subcutaneous injections (2 × 106 units/m2) of IFN-αn1, -β, -γ or placebo 3 times a week for 6 weeks and cryotherapy with liquid nitrogen. Subjects were followed ⩽1 year. Among patients followed ⩾12 weeks, two-thirds had a complete response. No significant differences in rates of complete response (P = .37) or reappearance of a wart at the initial site (P = .20) were noted among the treatment groups. However, patients who received IFN-β or -γ developed new warts at a significantly lower frequency (P = .02). IFN administration was associated with side effects but was well tolerated. IFN-β was the least toxic of the 3 preparations and had the best therapeutic ratio.Keywords
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