The nature of virus-like particles in the paraxial muscles of idiopathic scoliosis

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Abstract
Virus-like particles (VLP) were identified by EM in the skeletal muscles (paraxials) of 6 [human] cases of idiopathic scoliosis. These particles closely resembled VLP reported in the skeletal muscles in other conditions, e.g., Reye''s syndrome, polymyositis, malignant hyperthermia and chronic myopathy. Specific staining showed that these structures are composed of glycogen in a crystalline form. Using coxsackie B infected tissue culture cells as a control, these viruses, which are of similar shape and size to the VLP, were unstained using this specific staining method.