Stimulation of Platelet Production by Serum of Platelet-Depleted Rats

Publisher Website
Google Scholar
Abstract
Four subcutaneous injections, given during a 2-day period, of serum from platelet-depleted rats into untreated or splenectomized rats caused an increase in the number of circulating platelets to as much as 167% of the initial count. The rise in peripheral platelet count began 2 days after the first injection, reached a peak at 5 days, then declined to control values at 8 days. Equal amounts of serum from untreated donors did not produce this response. The results indicate that the active serum contains an agent (thrombopoietin) that stimulates production of blood platelets.

This publication has 0 references indexed in Scilit: