Introduction to immune cell signalling
- 1 March 2005
- journal article
- review article
- Published by Cambridge University Press (CUP) in Parasitology
- Vol. 130 (S1) , S3-S9
- https://doi.org/10.1017/s0031182005008115
Abstract
The dynamic interaction of cells of the immune system with other cells, antigens and secreted factors determines the nature of an immune response. The response of individual cells is governed by the sequence of intracellular signalling events triggered following the association of cell surface molecules during cell-cell contact or the detection of soluble molecules of host or pathogen origin. In this review we will first outline the general principles of intracellular signal transduction. We will then describe the signalling pathways triggered following the recognition of antigen, as well as the detection of cytokines, and discuss how the signalling pathways activated regulate the effector response.Keywords
This publication has 57 references indexed in Scilit:
- Targeting the Jak/STAT pathway for immunosuppressionAnnals of the Rheumatic Diseases, 2004
- Conformational Coupling: A Physiological Calcium Entry MechanismScience's STKE, 2004
- The expanding family of MyD88-like adaptors in Toll-like receptor signal transductionMolecular Immunology, 2004
- Jak3 and the pathogenesis of severe combined immunodeficiencyMolecular Immunology, 2004
- The roles of transcription factors in B lymphocyte commitment, development, and transformationJournal of Leukocyte Biology, 2004
- 20 years of Ins(1,4,5)P3, and 40 years beforeNature Reviews Molecular Cell Biology, 2003
- Calcium signalling: dynamics, homeostasis and remodellingNature Reviews Molecular Cell Biology, 2003
- Nuclear lipid signallingNature Reviews Molecular Cell Biology, 2003
- Cytokines and their role in lymphoid development, differentiation and homeostasisCurrent Opinion in Allergy and Clinical Immunology, 2002
- Signaling and Transcription in T Helper DevelopmentAnnual Review of Immunology, 2000