Cardiovascular Response to Rapid Phenytoin Infusion During Seizures in Paralyzed Rats

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Abstract
• The maximum rate at which phenytoin may be safely administered without inducing hypotension has been evaluated in nonconvulsing animals and man; no comparable information during convulsions in either animals or man is available. Comparison of blood pressure and ECG responses to rapid phenytoin infusion in nonconvulsing rats and in rats during bicuculline-induced status epilepticus suggests that the hypertensive response of convulsions may protect against phenytoin-induced hypotension, thus indicating that more rapid administration of phenytoin during convulsions might be possible with careful monitoring.