Patient-Specific Cytotoxic T-Lymphocyte Cross-Recognition of Naturally Occurring Variants of a Human Immunodeficiency Virus Type 1 (HIV-1) p24gagEpitope by HIV-1-Infected Children
- 15 May 2001
- journal article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 75 (10) , 4941-6
- https://doi.org/10.1128/jvi.75.10.4941-4946.2001
Abstract
We tested seven human immunodeficiency virus-infected children for their cytotoxic T-lymphocyte (CTL) activities towards the p24gagQASQEVKNW epitope and its nine variant sequences. Our data confirm that most, but not all, CTL responses are broadly cross-specific. For the first time, we show the high interpatient variability in cross-recognition of mutant CTL epitopes. These interindividual variations in the CTL response to the same epitope should be taken into account in the design and the evaluation of vaccines.Keywords
This publication has 23 references indexed in Scilit:
- HIV-1 Nomenclature ProposalScience, 2000
- AIDS and HIV vaccinesVaccine, 1999
- Cross-Clade-Specific Cytotoxic T Lymphocytes in HIV-1-Infected ChildrenVirology, 1998
- Cross-Clade Envelope Glycoprotein 160-Specific CD8+Cytotoxic T Lymphocyte Responses in Early HIV Type 1 Clade B InfectionAIDS Research and Human Retroviruses, 1998
- Clade B-based HIV-1 vaccines elicit cross-clade cytotoxic T lymphocyte reactivities in uninfected volunteersProceedings of the National Academy of Sciences, 1997
- Immune correlates of protection from HIV infection and AIDSImmunology Today, 1997
- Novel, Cross-Restricted, Conserved, and Immunodominant Cytotoxic T Lymphocyte Epitopes in Slow Progressors in HIV Type 1 InfectionAIDS Research and Human Retroviruses, 1996
- Bound Water Structure and Polymorphic Amino Acids Act Together to Allow the Binding of Different Peptides to MHC Class I HLA-B53Immunity, 1996
- Recombination in HIV-1Nature, 1995
- Multispecific and heterogeneous recognition of the gag protein by cytotoxic T lymphocytes (CTL) from HIV-infected patients: factors other than the MHC control the epitopic specificitiesClinical and Experimental Immunology, 1994