A novel germ-line JKtranscript starting immediately upstream of JK1
Open Access
- 1 January 1989
- journal article
- research article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 17 (17) , 6809-6819
- https://doi.org/10.1093/nar/17.17.6809
Abstract
Germ-line transcripts of the immunoglobulin (Ig) and T cell receptor loci are thought to be involved in the control of V gene rearrangement by rendering these loci accessible to the recombinases. We have analyzed the transcriptional activity of germ-line K alleles in two bone marrow-derived Abelson murine leukemia virus transformed pre-B cells: 300-19, a null cell line, and P a μ-producing line. We found a novel germ-line JK transcript starting immediately upstream of JK1 and spliced to CK. The potential role of this transcript in the opening of the Ig K locus as well as in the ordered usage of JK segments is discussed.This publication has 39 references indexed in Scilit:
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