Endemic Goitre of the Island of Krk Studied With I131

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Abstract
The 3, 6, 24 and 48-hour thyroidal I131 uptake and the urinary excretion of I127 and I131 were studied among subjects in the goitrous areas of the island of Krk. The results showed an avidity of the thyroid gland for radioactive iodine, the uptake ranging between 57% of the administered dose for more severe and 45% for less severe goitrous areas. Subjects from nongoitrous areas of the same island as well as controls from the nongoitrous area of Zagreb showed a thyroidal I131 uptake of less than 40%. The urinary I127 and I131 excretions were lower among goitrous subjects from the island than among controls in Zagreb. From these data it can be concluded that the incidence of goitre on the island of Krk is due to lack of iodine. However, according to an earlier study on the island of Krk no difference was found in the iodine supply between various areas. It could be assumed that some other factors impair the utilization of iodine in the goitrous areas, thus creating a relative deficiency.

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