Cushing's Disease: A Hypothalamic Flush?

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Abstract
IN 1969 Liddle and Shute divided the historical evolution of Cushing's syndrome as a clinical entity into four phases.1 During the first phase, Harvey Cushing described the syndrome in patients with basophilic pituitary adenomas. During the second phase, the syndrome was correctly attributed to hypercortisolism. During the third phase, the three basic causes of hypercortisolism were described: 59 per cent of cases are due to excessive secretion of ACTH by the pituitary gland (Cushing's disease); 25 per cent are due to autonomous secretion of cortisol by an adrenocortical neoplasm; and 16 per cent are due to hypersecretion of cortisol in . . .