Discrepant Platelet Kinetic Data Obtained in Rats Using the Platelet Labels 51Cr and DFP 3H

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Abstract
Platelet kinetics in a single species, the rat, have been studied utilizing two different labels – 51Cr, and DFP 3H. Disappearance of isotope was primarily linear with time with the 51Cr tag, but exponential with DFP 3H. This difference could not be ascribed to a toxic effect of the DFP or its carrier, propylene glycol, or to nonuniform uptake of the labels by platelets of differing mean age. It is suggested, therefore, that DFP is preferentially lost from the platelet either by elution or by release of a platelet component to which this isotope binds. The possibility is discussed that such loss is concerned with platelet function, perhaps in support of endothelial integrity.

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