Separation and identification of N4-(guanosin-7-yl)-4-aminoquinoline 1-oxide, a novel nucleic acid adduct of carcinogen 4-nitroquinoline 1-oxide
Open Access
- 1 August 1991
- journal article
- research article
- Published by Oxford University Press (OUP) in Carcinogenesis: Integrative Cancer Research
- Vol. 12 (8) , 1523-1525
- https://doi.org/10.1093/carcin/12.8.1523
Abstract
A novel nucleic acid adduct of the carcinogen 4-nitroquinoline 1-oxide, N4-(guanosin-7-yl)-4-aminoquinoline 1-oxide, was separated and identified after RNA was treated with activated 4-hydroxyaminoquinoline 1-oxide. This is the first report of a 7-arylaminated guanine adduct produced by arylaminating carcinogens.Keywords
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