Genetic Testing-- Present and Future
- 15 September 2000
- journal article
- review article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 289 (5486) , 1890-1892
- https://doi.org/10.1126/science.289.5486.1890
Abstract
Detecting disease carrying mutations in families with a history of a particular hereditary genetic disease offers those individuals who test positive the opportunity to take prophylactic measures. In a TechView, Yan, Kinzler and Vogelstein discuss the various methods for detecting disease mutations and their strengths and weaknesses.Keywords
This publication has 19 references indexed in Scilit:
- Conversion of diploidy to haploidyNature, 2000
- The protein truncation test: A reviewHuman Mutation, 1999
- The human genome project and the future of diagnostics, treatment, and preventionThe Lancet, 1999
- High-throughput single-strand conformation polymorphism analysis by automated capillary electrophoresis: Robust multiplex analysis and pattern-based identification of allelic variantsHuman Mutation, 1999
- Enzymatic and chemical cleavage methodsElectrophoresis, 1999
- Mutation Detection and Mutation Databasescclm, 1998
- Genetic testing: The problems and the promiseNature Biotechnology, 1997
- The Use and Interpretation of CommercialAPCGene Testing for Familial Adenomatous PolyposisNew England Journal of Medicine, 1997
- Molecular Diagnosis of Familial Adenomatous PolyposisNew England Journal of Medicine, 1993
- Analyzing and comparing nucleic acid sequences by hybridization to arrays of oligonucleotides: Evaluation using experimental modelsGenomics, 1992