Therapy of Hairy-Cell Leukemia

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Abstract
Hairy-cell leukemia is a well-defined disorder characterized by splenomegaly, pancytopenia, and morphologically typical neoplastic mononuclear cells in the blood and bone marrow. Since the description of this disease as leukemic reticuloendotheliosis by Bouroncle et al. in 1958,1 there has been considerable controversy regarding the cell line of origin of the neoplastic hairy cells. Present evidence indicates that hairy-cell leukemia is a lymphoproliferative disease that usually originates in B lymphocytes. The most convincing point regarding this conclusion is the demonstration of immunoglobin synthesis by hairy cells both in vitro and in vivo.2 , 3 Cell-marker studies in hairy-cell leukemia also indicate a spectrum . . .