Innate immune sensing and its roots: the story of endotoxin
Top Cited Papers
- 1 February 2003
- journal article
- review article
- Published by Springer Nature in Nature Reviews Immunology
- Vol. 3 (2) , 169-176
- https://doi.org/10.1038/nri1004
Abstract
How does the host sense pathogens? Our present concepts grew directly from longstanding efforts to understand infectious disease: how microbes harm the host, what molecules are sensed and, ultimately, the nature of the receptors that the host uses. The discovery of the host sensors--the Toll-like receptors--was rooted in chemical, biological and genetic analyses that centred on a bacterial poison, termed endotoxin.Keywords
This publication has 85 references indexed in Scilit:
- Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartmentsEuropean Journal of Immunology, 2002
- Lipopolysaccharide EndotoxinsAnnual Review of Biochemistry, 2002
- The serine protease inhibitor antithrombin III inhibits LPS‐mediated NF‐κB activation by TLR‐4FEBS Letters, 2001
- A MAP Kinase Targeted by Endotoxin and Hyperosmolarity in Mammalian CellsScience, 1994
- κB-like Motifs Regulate the Induction of Immune Genes in DrosophilaJournal of Molecular Biology, 1993
- Drosophila Toll and IL-1 receptorNature, 1991
- Structure and Function of Lipopolysaccharide Binding ProteinScience, 1990
- CD14, a Receptor for Complexes of Lipopolysaccharide (LPS) and LPS Binding ProteinScience, 1990
- Interleukin 1-induced pathophysiology: Induction of cytokines, development of histopathologic changes, and immunopharmacologic interventionClinical Immunology and Immunopathology, 1989
- Das putride Gift, die Bakterien, die putride Infection oder Intoxication und die SepticämieVirchows Archiv, 1874