Two-dimensional nuclear magnetic resonance spectra of selected tricyclic antidepressants.
- 1 January 1987
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 35 (1) , 188-194
- https://doi.org/10.1248/cpb.35.188
Abstract
Two-dimensional nuclear magnetic resonance (2D NMR) spectroscopy has been used to assign 13C spectra of the tricyclic antidepressants imipramine and chlorimipramine. The 2D-INADEQUATE method was used to unambiguously assign the aromatic spectral region for the former compound. Errors in previous literature assignments based on 1D methods were corrected. For chlorimipramine the pitfalls of classical substituent chemical shift arguments for 13C assignments and the difficulties of 1D selective 1H irradiation in overlapped systems are contrasted with the power and relative simplicity of the 2D-13C, 1H-correlated and 13C, 1H RELAY methods.Keywords
This publication has 1 reference indexed in Scilit:
- Interaction of antidepressant drugs with lipid bilayers studied by high-resolution carbon-13(13C-) and high-power deuterium nuclear magnetic resonance (2H-NMR) spectroscopy: The manner of binding as deduced from the differential line-broadening of 13C-NMR signals.CHEMICAL & PHARMACEUTICAL BULLETIN, 1985