Participation of Erythromycin and Carbomycin in Combined Antibiotic Action in vitro.

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Abstract
In terms of their behavior in combinations with other antibiotics, as measured by bactericidal rate in vitro, erythromycin and carbomycin fall in a group with aureomycin, chloramphenicol and terramycin. Thus erythromycin or carbomycin in combination with group I drugs may result in synergism against certain micro-organisms which are relatively resistant to group I agents (penicillin, bacitracin, streptomycin) or may occasionally give antagonism when acting on microorganisms highly susceptible to group I drugs. With groups II drugs (aureomycin, chloramphenicol, terramycin), these 2 new drugs do not appear to be synergistic or antagonistic, but may be additive. Some uses of such drug combinations in laboratory and clinic are discussed.