IODATION DE PROTEINES DE LA THYROIDE HUMAINE (NORMALE ET PATHOLOGIQUE)

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Abstract
The radioiodine distribution between the different soluble thyroid proteins was studied after 125I administration, in normal human thyroid tissues and in several pathological tissues, by sucrose gradient ultra-centrifugation. In normal human, the most part of the radioactivity is bound to 19 S thyroglobulin, and also, for a small percentage, to 12 S and 27 S proteins. The repartition seems similar from 2 hours to 7 days after isotope administration. The stable iodine proportion bound to the proteins precipitating between 35–50 per cent of ammonium sulfate saturation is almost the same as the radioactive iodine percentage precipitating in the same zone. In the pathological thyroids, the radioactivity distribution between the 12, 19 and 27 S proteins gives normal results in toxic adenoma, simple goiter and in a tumour, but is different from normal results in a Hashimoto thyroiditis.

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