Synthesis of podophyllum lignans via an isolable o-quinonoid pyrone
- 1 January 1987
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 23,p. 1797-1798
- https://doi.org/10.1039/c39870001797
Abstract
The 2-benzopyran-3-one (7) is a stable, isolable, and useful Diels–Alder diene; its adduct (10) formed with dimethyl fumarate is transformed in three steps into methyl epipodophyllate (14) which gives epipodophyllotoxin (2)(81%) by direct lactonisation (ZnCl2–tetrahydrofuran–4 Å molecular sieves).Keywords
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