Dexamethasone and Osteonecrosis

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Abstract
Four cases are reported in whom osteonecrosis followed after Dexamethasone was administered in high dosage for a short time to mduce cerebral and spinal cord oedema. Although corticosteroids have been implicated in the development of osteonecrosis, the delay from corticosteroid administration to the development of symptoms (9–30 months), with further delay in radiographic changes (9–36 months) may result in diagnostic confusion.

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